Acquired risk factors and incident atrial fibrillation according to age and genetic predisposition

Figures

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  Figure 1. Multivariable-adjusted hazard ratios (95% confidence intervals) of incident atrial fibrillation associated with risk factors in different age groups (A) and genetic risk groups (B). Models were adjusted for sex, age, ethnicity, and the use of lipid-lowering medication and were mutually adjusted for individual risk factors. Statistical significance was defined as a Bonferroni-corrected threshold of P < .002 (.05/23). LDL-C, low-density lipoprotein cholesterol; CRP, C-reactive protein; COPD, chronic obstructive pulmonary disease

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  Figure 2. Multivariable-adjusted hazard ratios (95% confidence intervals) of incident atrial fibrillation associated with risk scores in different age groups (A) and genetic risk groups (B). Models were adjusted for sex, age, ethnicity, the use of lipid-lowering medication and individual risk factors that were not included in the risk score. Statistical significance was defined using Bonferroni-corrected thresholds of P < .013 (.05/4)

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  Figure 3. Partial population-attributable risk percentages for incident atrial fibrillation associated with risk factors in different age groups (A) and genetic risk groups (B). Values are expressed as population-attributable risk percentages (95% confidence intervals). Models were adjusted for sex, age, ethnicity, and the use of lipid-lowering medication and were mutually adjusted for individual risk factors. Since this threshold for determining an increase in risk is 0, the risk factors with negative population-attributable risk percentages were excluded from the models and were truncated at the limit of 0. LDL-C, low-density lipoprotein cholesterol; CRP, C-reactive protein; COPD, chronic obstructive pulmonary disease

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  Figure 4. Partial population-attributable risk percentages for incident atrial fibrillation associated with combinations of risk factors by age group (A) and genetic risk group (B). Models were adjusted for sex, age, ethnicity, the use of lipid-lowering medication and individual risk factors that were not included in the risk score