Key result
High polygenic and clinical risk burden linked to a ~48% lifetime risk of AF.
Why the study?
What is the lifetime risk of atrial fibrillation considering genetic predisposition and clinical risk factor burden in individuals without AF at age 55?
Cohort (n=4,606)
What is the lifetime risk of atrial fibrillation considering genetic predisposition and clinical risk factor burden in individuals without AF at age 55?
Absolute Event Rate: 48.2% vs 22.3%
p-value: p=<0.001
Both polygenic risk and clinical risk factor burden substantially influence the lifetime risk of atrial fibrillation, which is 37.1% overall for individuals free of AF at age 55.
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May refine AF counseling with combined risk scores; extends observational data but leaves open intervention effects.
Weng et al. (2017) conducted a cohort in Atrial fibrillation (n=4,606). High polygenic and clinical risk factor burden vs. Low polygenic and clinical risk factor burden was evaluated on Lifetime risk of atrial fibrillation >55 years of age (p=<0.001). High polygenic and clinical risk factor burden was associated with a 48.2% lifetime risk of atrial fibrillation, compared to 22.3% in individuals with low risk.
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