What question did this study set out to answer?

Determine whether progesterone receptor status provides independent predictive value over estrogen receptor status alone for patients receiving adjuvant endocrine therapy for breast cancer.

May 12, 2003Journal of Clinical Oncology

Progesterone Receptor Status Significantly Improves Outcome Prediction Over Estrogen Receptor Status Alone for Adjuvant Endocrine Therapy in Two Large Breast Cancer Databases

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Authors

VBValérie‐Jeanne BardouConservatoire National des Arts et Métiers GAGrazia ArpinoUniversity of Naples Federico II RERichard ElledgeThe University of Texas Health Science Center at San Antonio

Discussion

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Implication

Database analysis demonstrates improved outcome prediction with progesterone receptor status in breast cancer, suggesting routine inclusion when estimating endocrine therapy benefit.

Key Points

Determine whether progesterone receptor status provides independent predictive value over estrogen receptor status alone for patients receiving adjuvant endocrine therapy for breast cancer.
Examined clinical and biomarker records across two large breast cancer databases.
Evaluated the predictive capacity of progesterone receptor status alongside estrogen receptor status for adjuvant endocrine therapy outcomes.
Accurately measured progesterone receptor status was identified as an independent predictive factor for clinical benefit from adjuvant endocrine therapy.
Progesterone receptor status substantially alters expected relative risk reductions compared to evaluation by estrogen receptor status alone.

Cite This Study

Bardou et al. (2003) studied this question.

synapsesocial.com/papers/69d901e2d2f7327e70ae4c48 https://doi.org/10.1200/jco.2003.09.099

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Implication

Database analysis demonstrates improved outcome prediction with progesterone receptor status in breast cancer, suggesting routine inclusion when estimating endocrine therapy benefit.

Progesterone Receptor Status Significantly Improves Outcome Prediction Over Estrogen Receptor Status Alone for Adjuvant Endocrine Therapy in Two Large Breast Cancer Databases

Discussion

Member takes

Implication

Key Points

Cite This Study

Progesterone Receptor Status Significantly Improves Outcome Prediction Over Estrogen Receptor Status Alone for Adjuvant Endocrine Therapy in Two Large Breast Cancer Databases

Discussion

Member takes

Implication

Key Points

Cite This Study

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