What question did this study set out to answer?

Determine whether brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) regulate synaptic transmission and long-term depression in the developing visual cortex.

December 1, 1996Journal of Neurophysiology

Brain-derived neurotrophic factor blocks long-term depression in rat visual cortex

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Authors

YAYukio AkaneyaNew York University TTTadaharu TsumotoRIKEN Center for Brain Science HHH. HatanakaUniversidade Federal de Uberlândia

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Implication

Electrophysiological study demonstrates that brain-derived neurotrophic factor prevents long-term depression in rat visual cortex, suggesting neurotrophins protect developing neural circuits.

Key Points

Determine whether brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) regulate synaptic transmission and long-term depression in the developing visual cortex.
Recorded layer II/III field responses to layer IV stimulation in visual cortical slices from young rats.
Assessed synaptic responses following low-frequency stimulation (1 Hz for 15 minutes) under perfusion with BDNF, NGF, and the tyrosine kinase inhibitor K252a.
Perfusion with 20 ng/ml BDNF completely prevented low-frequency stimulation from inducing long-term depression without altering baseline synaptic transmission, whereas NGF exerted no protective effect.
Higher concentrations of BDNF (200 ng/ml) enhanced baseline field responses elicited by 0.1 Hz stimulation.
The receptor tyrosine kinase inhibitor K252a blocked the inhibitory effect of BDNF on long-term depression, and K252a alone augmented depression magnitude relative to controls.

Cite This Study

Akaneya et al. (1996) studied this question.

synapsesocial.com/papers/69d903a87e3358c846d17ff1 https://doi.org/10.1152/jn.1996.76.6.4198

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Implication

Electrophysiological study demonstrates that brain-derived neurotrophic factor prevents long-term depression in rat visual cortex, suggesting neurotrophins protect developing neural circuits.

Brain-derived neurotrophic factor blocks long-term depression in rat visual cortex

Discussion

Member takes

Implication

Key Points

Cite This Study

Brain-derived neurotrophic factor blocks long-term depression in rat visual cortex

Discussion

Member takes

Implication

Key Points

Cite This Study

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