Randomized trial reveals stenting lowers 4-year stroke or death risk compared to medical therapy alone in asymptomatic carotid stenosis, indicating procedural benefits over surgery.
Among patients with high-grade stenosis without recent symptoms, the addition of stenting led to a lower risk of a composite of perioperative stroke or death or ipsilateral stroke within 4 years than intensive medical management alone. Carotid endarterectomy did not lead to a significant benefit. (Funded by the National Institute of Neurological Disorders and Stroke and others; CREST-2 ClinicalTrials.gov number, NCT02089217.).
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Brott et al. (2025) studied this question.
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