Metabolomics- and proteomics-based multi-omics integration reveals early metabolite alterations in sepsis-associated acute kidney injury

Pengfei Huang; Yanqi Liu; Yue Li; Xin Yu; Chuanchuan Nan; Yinghao Luo; Yating Feng; Nana Jin; Yahui Peng; Dawei Wang; Yang Zhou; Feiyu Luan; Xinran Wang; Xibo Wang; Hongxu Li; Yuxin Zhou; Weiting Zhang; Yuhan Liu; Mengyao Yuan; Yuxin Zhang; Yu‐Chen Song; Xiao Yu; Libo Shen; Kaijiang Yu; Mingyan Zhao; Lixin Cheng; Changsong Wang

doi:10.1186/s12916-025-03920-7

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Abstract

We proposed a blood metabolite model consisting of inosine, creatine, and 3-hydroxybutyric acid for the early screening of SA-AKI. Future studies will observe the performance of these metabolites in other clinical populations to evaluate their diagnostic role.

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Huang et al. (2025) studied this question.

synapsesocial.com/papers/69d9063a0e1b46d093ae2b90 https://doi.org/10.1186/s12916-025-03920-7

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Metabolomics- and proteomics-based multi-omics integration reveals early metabolite alterations in sepsis-associated acute kidney injury

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Abstract

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Metabolomics- and proteomics-based multi-omics integration reveals early metabolite alterations in sepsis-associated acute kidney injury

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Abstract

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