Why the study?
What is the residual stroke or systemic embolism risk in patients with atrial fibrillation prescribed oral anticoagulants?
What is the residual stroke or systemic embolism risk in patients with atrial fibrillation prescribed oral anticoagulants?
Despite oral anticoagulation, high-risk patients with atrial fibrillation maintain a clinically significant residual stroke/SE risk of 1.5% to 2.5% per year, highlighting the need for additional prevention strategies.
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Residual stroke risk on OAC warrants adjunctive strategies in high-risk AF; extends meta-analytic support for targeted prevention trials.
AF type, CHA₂DS₂-VASc score, and stroke history can identify patients with AF, who despite oral anticoagulation have a residual stroke/SE risk of 1.5% to 2.5% per year. Evaluation of additional stroke/SE prevention strategies in high-risk patients is warranted.
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Johnson et al. (2024) studied this question.
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