What question did this study set out to answer?

To investigate the physical mechanisms and cellular structures that position human chromosomes and reduce chromosome scattering during early mitosis.

July 2, 2019eLifeOpen Access

Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis

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Authors

ABAlexander JR BoothUniversity of Dundee ZYZuojun YueUniversity of Dundee JEJohn K. EykelenboomUniversity of Dundee

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Implication

Cell biology study demonstrates that acto-myosin networks contract nuclear envelope remnants to cluster human chromosomes during mitosis, indicating a microtubule-independent alignment mechanism.

Key Points

To investigate the physical mechanisms and cellular structures that position human chromosomes and reduce chromosome scattering during early mitosis.
Quantified dynamic changes in chromosome-scattering volume (CSV) in human cells following nuclear envelope breakdown (NEBD).
Investigated the roles of spindle microtubules, the LINC complex, and acto-myosin network contraction in regulating chromosome compaction.
Chromosome-scattering volume decreases rapidly after NEBD via a mechanism largely independent of spindle microtubules.
An acto-myosin network forms on the cytoplasmic nuclear envelope surface in a LINC complex-dependent manner prior to NEBD and persists on envelope remnants.
Myosin-II-mediated contraction of this remnant network physically compacts chromosomes to promote timely congression and accurate segregation.

Cite This Study

Booth et al. (2019) studied this question.

synapsesocial.com/papers/69d911ceda3af5b1d0835845 https://doi.org/10.7554/elife.46902

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Implication

Cell biology study demonstrates that acto-myosin networks contract nuclear envelope remnants to cluster human chromosomes during mitosis, indicating a microtubule-independent alignment mechanism.

Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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