What question did this study set out to answer?

To determine whether fibronectin type III (FNIII) repeats lacking the canonical RGD motif can support cell adhesion and intracellular signaling through activated beta1 integrins.

December 1, 1997Journal of Biological ChemistryOpen Access

Fibronectin Type III Repeats Mediate RGD-independent Adhesion and Signaling through Activated β1 Integrins

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To determine whether fibronectin type III (FNIII) repeats lacking the canonical RGD motif can support cell adhesion and intracellular signaling through activated beta1 integrins.
Experimentally activated beta1 integrins across multiple cell types in vitro.
Assayed cell adhesion, spreading, and downstream signaling cascades on non-RGD-containing FNIII repeats derived from extracellular matrix proteins and cytokine receptors.
Multiple cell types adhered and spread on non-RGD FNIII domains following experimental activation of beta1 integrins.
Integrin engagement with isolated FNIII domains induced focal adhesion kinase phosphorylation, stress fiber assembly, and focal contact formation.

Authors

GCG Chi-RossoBiogen (United States)PGPhilip J. GotwalsNovartis (Switzerland)JYJianliang YangChinese Academy of Medical Sciences & Peking Union Medical College

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Implication

In vitro study reveals that activated beta1 integrins bind RGD-deficient fibronectin type III repeats across multiple cell types, highlighting broader mechanisms of cell-matrix signaling.

Cite This Study

Chi-Rosso et al. (1997) studied this question.

synapsesocial.com/papers/69d913989a6164e50fa3bfa7 https://doi.org/10.1074/jbc.272.50.31447

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Implication

In vitro study reveals that activated beta1 integrins bind RGD-deficient fibronectin type III repeats across multiple cell types, highlighting broader mechanisms of cell-matrix signaling.

Fibronectin Type III Repeats Mediate RGD-independent Adhesion and Signaling through Activated β1 Integrins

Key Points

Discussion

Implication

Cite This Study

Fibronectin Type III Repeats Mediate RGD-independent Adhesion and Signaling through Activated β1 Integrins

Key Points

Discussion

Implication

Cite This Study

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