Why the study?
Does androgen deprivation therapy increase large artery stiffness and alter metabolic parameters in males with prostate cancer?
Population
22 males with prostate cancer, mean age 67 +/- 8 years
Comparison
Androgen deprivation therapy over a 6-month period vs Baseline measurements and a subgroup with…
Design
Cohort
Follow-up
6 months
Authors
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May heighten CV risk via stiffness and insulin changes in prostate cancer; hypothesis-generating for randomized confirmation.
Does androgen deprivation therapy increase large artery stiffness and alter metabolic parameters in males with prostate cancer?
Androgen deprivation therapy in men with prostate cancer increases central arterial stiffness and insulin resistance, potentially elevating cardiovascular risk.
Smith et al. (2001) studied this question.
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