July 29, 2014Hypertension

Differences in Cell-Type–Specific Responses to Angiotensin II Explain Cardiac Remodeling Differences in C57BL/6 Mouse Substrains

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Why the study?

Does angiotensin II administration induce different cardiac remodeling responses in C57BL/6J versus C57BL/6N mice?

Structured PICO

Does angiotensin II administration induce different cardiac remodeling responses in C57BL/6J versus C57BL/6N mice?

Population

Male C57BL/6J and C57BL/6N mice, and F2 animals

Intervention

Subacute (48 hours) and chronic (14 days) administration of angiotensin II (500 ng/kg per day)

Comparator

Comparison between C57BL/6J and C57BL/6N mouse substrains

Outcome

Cardiac remodeling (fibrosis, left ventricular weight/body weight ratio, cardiac expression of markers of left ventricular hypertrophy)surrogate

C57BL/6N mice exhibit a greater fibrogenic and hypertrophic response to angiotensin II than C57BL/6J mice, driven by differences in macrophage and fibroblast activation.

Discussion

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Implication

C57BL/6 substrain choice may influence angiotensin II remodeling outcomes in mice; leaves open optimal model selection and human translation.

Cite This Study

Cardin et al. (2014) studied this question.

synapsesocial.com/papers/69d91a91ccb0bba5a5684133 https://doi.org/10.1161/hypertensionaha.114.04067

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Implication

C57BL/6 substrain choice may influence angiotensin II remodeling outcomes in mice; leaves open optimal model selection and human translation.

Differences in Cell-Type–Specific Responses to Angiotensin II Explain Cardiac Remodeling Differences in C57BL/6 Mouse Substrains

Structured PICO

Discussion

Implication

Cite This Study

Differences in Cell-Type–Specific Responses to Angiotensin II Explain Cardiac Remodeling Differences in C57BL/6 Mouse Substrains

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider