Genetic background significantly influences cardiac function and calcium regulation in mouse models, highlighting the importance of strain selection in preclinical cardiovascular research.
Strain differences affect mouse cardiac phenotypes; leaves open optimal model selection for translational research.
These results demonstrate that a different genetic background is associated with physiological differences in cardiac function in vivo and differences in morphology, contractility, and Ca(2+) handling at the cellular level.
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Shah et al. (2010) studied this question.
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