Population
Ventricular myocytes from 4-month-old transgenic mice overexpressing the alpha1 subunit of L-type Ca2+…
Comparison
Overexpression of the alpha1 subunit of L-type… vs Ventricular myocytes from nontransgenic…
Design
Preclinical
Authors
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Suggests compensatory Ca2+ remodeling preserves homeostasis in overexpression models; leaves open relevance to human HF or arrhythmias.
A sustained increase in Ca2+ influx via overexpressed L-type Ca2+ channels triggers a coordinated remodeling of Ca2+ handling, including upregulated Na+-Ca2+ exchange and SR Ca2+ recycling, to maintain cellular Ca2+ homeostasis.
Song et al. (2002) studied this question.
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