Key result
Caveolae-targeted LTCC activator or inhibitor proteins did not affect cardiac hypertrophy or nuclear factor of activated T-cells activity in mice subjected to pressure overload compared with controls.
Population
Heart-specific transgenic mice subjected to pressure overload or neurohumoral agonist infusion
Comparison
Transgenic overexpression of putative… vs Control mice
Design
Preclinical
Follow-up
2 or 12 weeks (for pressure overload)
Authors
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Caveolar LTCC-NFAT signaling may promote hypertrophy in feline models; leaves open in vivo human relevance and therapeutic targeting.
In vivo mouse models demonstrate that caveolae-localized L-type Ca2+ channels do not regulate cardiac hypertrophy or function, contrasting with previous in vitro findings.
Correll et al. (2017) studied Cardiac hypertrophy. Caveolae-targeted LTCC activator or inhibitor protein vs. Control mice was evaluated on Cardiac hypertrophy and nuclear factor of activated T-cells activity. Caveolae-targeted LTCC activator or inhibitor proteins did not affect cardiac hypertrophy or nuclear factor of activated T-cells activity in mice subjected to pressure overload compared with controls.
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