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We note increasing xylazine positivity among samples of illicit fentanyl in Los Angeles, California. The distribution of xylazine concentration is highly skewed, with a small number of very high concentration samples, and majority with <1 %. Nevertheless, more research is needed to study the health impacts of even the low concentration xylazine that is most predominant here; the average participant may still be exposed to a physiologically significant dose of xylazine.
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Friedman et al. (2025) studied this question.
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