Experimental study demonstrates advanced oxidation protein products trigger neuroinflammation in spinal cord injury models, suggesting potential therapeutic targets for limiting secondary damage.
Collectively, these data indicated AOPPs as biomarkers of oxidative stress, modulating inflammatory response in SCI by multiple signaling pathways, which also included the induction of NADPH oxidase dependent ROS, and NLRP3-mediated pyroptosis, and activation of MAPKs and NF-κB.
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Liu et al. (2020) studied this question.