Why the study?
Does ADAM 15 mediate human mesangial cell migration and matrix restructuring in vitro?
Population
Human glomerular mesangial cells (HMC) in vitro
Comparison
Antibodies to individual domains of ADAM 15… vs Control oligonucleotide and serum-free medium
Design
Preclinical
Authors
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In vitro ADAM15 inhibition may limit mesangial migration; leaves open its role in glomerular disease.
Does ADAM 15 mediate human mesangial cell migration and matrix restructuring in vitro?
ADAM 15 acts as an active metalloproteinase that is essential for human mesangial cell migration and matrix restructuring in vitro.
Martin et al. (2002) studied this question.