Clinically Relevant Changes for Cognitive Outcomes in Preclinical and Prodromal Cognitive Stages

Figures

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  Figure 1. Changes in Clinical Outcome Scores That Indicate Clinically Meaningful Differences (A) Cognitively unimpaired, (B) Mild Cognitive impairment. For MMSE, Animal Fluency, Letter S and Symbol Digit all mean difference scores are negative (see Table 2). ES = estimates of effect size.

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  Figure 2. ROC Curves From Logistic Regression Models Estimating Minimally Clinical Difference in CU, MCI, and Amyloid positive CU groups. (A) CU group (N=451). (B) MCI group (N=292). (C) Amyloid positive CU group (N=116). Performance of the best model (defined as lowest AIC including predictors with p < 0.1) and individual tests are shown in receiver operating curves (ROC). Further results are presented in eTables 3-6. Outcomes in A and C are a clinical change in Clinical Dementia Rating Sum of Boxes (CDR-SB) ≥0.5 and in C a clinical change in CDR-SB ≥1 point.