Why the study?
Does dexmedetomidine stabilize glucose-related hormones and lactate in non-diabetic patients under general anesthesia?
Does dexmedetomidine stabilize glucose-related hormones and lactate in non-diabetic patients under general anesthesia?
Dexmedetomidine administration during general anesthesia in non-diabetic patients stabilizes insulin and blood glucose while reducing stress hormones and lactate levels.
This is the authors' abstract. We don't add key points for this paper.
Dexmedetomidine loading dose 1 µg/kg and maintenance dose 0.25 µg/kg/h produces a stable insulin level and significant postoperative decreases in glucagon, cortisol, epinephrine and norepinephrine secretion with stable maintenance of intraoperative and postoperative blood glucose levels and decreased postoperative lactate levels in non-diabetic patients under general anesthesia.
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Supports dexmedetomidine for perioperative metabolic stability in non-diabetics; extends limited RCT evidence on stress hormone and lactate effects.
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Zhou et al. (2021) studied this question.
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