Walking the strand: Tip-enhanced Raman scattering (TERS) with precision probe positioning has been used to obtain high-quality Raman spectra of the nucleobases in a single RNA strand (see picture: foreground Raman spectrum, background atomic-force microscope tip positioned over the RNA strand). This procedure represents the first step towards direct and label-free single-biomolecule sequencing.
No takes yet. Share an insight, caveat, or question.
Bailo et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: