Why the study?
Does eplerenone improve proteinuria and nephrosclerosis in the L-NAME/SHR model?
Population
L-NAME/SHR model
Design
Preclinical
Authors
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Hypothesis-generating for eplerenone in proteinuric kidney disease; human trials needed before clinical consideration.
Does eplerenone improve proteinuria and nephrosclerosis in the L-NAME/SHR model?
Eplerenone reduces proteinuria and nephrosclerosis in a hypertensive animal model independent of hemodynamic changes.
Zhou et al. (2004) studied this question.
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