What question did this study set out to answer?

To determine how matrix metalloproteinase processing of extracellular matrix-bound VEGF alters its bioavailability and governs vascular patterning in tumors.

May 23, 2005The Journal of Cell BiologyOpen Access

Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors

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Authors

SLSunyoung LeeAjou University Hospital SJShahla M. JilaniTwitter (United States)GNGanka NikolovaUniversity of California, Los Angeles

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Implication

Experimental study reveals differential tumor vascular patterning driven by matrix metalloproteinase cleavage of VEGF, indicating extracellular matrix binding directs vessel architecture.

Key Points

To determine how matrix metalloproteinase processing of extracellular matrix-bound VEGF alters its bioavailability and governs vascular patterning in tumors.
Mapped matrix metalloproteinase (MMP) cleavage sites on matrix-bound VEGF isoforms.
Engineered recombinant forms of VEGF designed to mimic either MMP-cleaved or MMP-resistant states.
Assessed VEGF receptor 2 phosphorylation and biological neovascular patterns produced by the engineered variants in tumor models.
MMP cleavage releases matrix-bound VEGF isoforms into soluble fragments without altering overall VEGF receptor 2 phosphorylation levels relative to MMP-resistant forms.
MMP-cleaved VEGF selectively drives capillary dilation of preexisting vessels with only marginal intratumoral neovascularization.
MMP-resistant VEGF induces extensive proliferation of thin, highly branched neovascular networks throughout the tumor.

Cite This Study

Lee et al. (2005) studied this question.

synapsesocial.com/papers/69d9263ff20ef26330684434 https://doi.org/10.1083/jcb.200409115

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Implication

Experimental study reveals differential tumor vascular patterning driven by matrix metalloproteinase cleavage of VEGF, indicating extracellular matrix binding directs vessel architecture.

Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors

Discussion

Member takes

Implication

Key Points

Cite This Study

Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors

Discussion

Member takes

Implication

Key Points

Cite This Study

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