Investigation of exchange processes by two-dimensional NMR spectroscopy

Key Points

• To introduce and demonstrate a general two-dimensional nuclear magnetic resonance (NMR) spectroscopy technique for investigating exchange processes in molecular systems.
• Designed a generalized two-dimensional NMR framework to monitor dynamic chemical exchange and energy transfer pathways.
• Applied the technique across both liquid and solid molecular states to track relaxation and diffusion phenomena.
• Demonstrated the detection of chemical exchange and magnetization transfer driven by inter- and intramolecular relaxation in liquid systems.
• Successfully characterized spin diffusion and cross-relaxation processes in solid-state molecular systems.