What question did this study set out to answer?

To evaluate the clinical efficacy and adverse effect profile of antihypertensive drug classes using genetic variants as proxies for pharmacological action.

June 25, 2019CirculationOpen Access

Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects

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Why the study?

Genetic variants can be used to explore the efficacy and side effects of antihypertensive medications.

Do genetic variants related to nondihydropyridine CCBs inform on the risk of diverticulosis?

Design

Other

Authors

DGDipender GillPreventive Cardiology MGMarios K. GeorgakisVascular / Pulmonary Vascular FKFotios KoskeridisUniversity of Ioannina

Discussion

Member takes

Implication

Genetic proxies for nondihydropyridine CCBs suggest higher diverticulosis risk; leaves open causality and needs prospective trials.

Key Points

To evaluate the clinical efficacy and adverse effect profile of antihypertensive drug classes using genetic variants as proxies for pharmacological action.
Analyzed genetic variants associated with antihypertensive drug targets to evaluate both therapeutic efficacy and potential side effects.
Identified a potential adverse link between genetic proxies for nondihydropyridine calcium channel blockers and an increased risk of diverticulosis.
Demonstrated the utility of drug-target genetic variants to characterize unintended side effects of antihypertensive medications.

Structured PICO

Do genetic variants related to nondihydropyridine CCBs inform on the risk of diverticulosis?

Intervention

Nondihydropyridine calcium channel blockers (assessed via genetic variants)

Outcome

Diverticulosis risksafety

Genetic variants related to nondihydropyridine CCBs suggest a potential effect on diverticulosis risk, warranting further investigation.

Cite This Study

Gill et al. (2019) studied this question.

synapsesocial.com/papers/69d93ad2e6ab964fb0835948 https://doi.org/10.1161/circulationaha.118.038814

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Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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