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October 4, 2017British Journal of Dermatology

Interleukin-36 in hidradenitis suppurativa: evidence for a distinctive proinflammatory role and a key factor in the development of an inflammatory loop

Schapoor Hessam Michael Sand Thilo Gambichler Marina Skrygan I. Rüddel Falk G. Bechara

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Abstract

Our results showed a possible involvement of IL-36 cytokines in the inflammatory network of HS and a dysbalance between the agonistic and antagonistic cytokines in HS skin.

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Hessam et al. (2017) studied this question.

synapsesocial.com/papers/69d93b80c7f0c3ae80a3c5ed https://doi.org/10.1111/bjd.16019

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Hidradenitis suppurativa: a review of cause and treatmentReview · 2010 · 87 citations
2Acne Inversa: Evaluating Antimicrobial Peptides and ProteinsOriginal Research · 2012 · 74 citations
3Altered innate and adaptive immune responses in patients with hidradenitis suppurativaOriginal Research · 2006 · 124 citations
4Immunohistological pointers to a possible role for excessive cathelicidin (LL‐37) expression by apocrine sweat glands in the pathogenesis of hidradenitis suppurativa/acne inversaCase-Control Study · 2011 · 110 citations
5Two Novel IL-1 Family Members, IL-1δ and IL-1ε, Function as an Antagonist and Agonist of NF-κB Activation Through the Orphan IL-1 Receptor-Related Protein 2Original Research · 2001 · 286 citations

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