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October 4, 2016Neuro-Oncology184 citationsOpen Access

Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas

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GSGanesh M. ShankarHarvard UniversityMAMalak AbedalthagafiTufts UniversityRVRachael A. VaubelMayo Clinic

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Abstract

We define a subset of aggressive rhabdoid meningiomas that can be recognized using routine laboratory tests. We implicate ubiquitin deregulation in the pathogenesis of these high-grade malignancies. In addition, we show that familial and sporadic BAP1-mutated rhabdoid meningiomas are clinically aggressive, requiring intensive clinical management.

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Shankar et al. (2016) studied this question.

synapsesocial.com/papers/69d9458e9a6164e50fa3c6c8https://doi.org/10.1093/neuonc/now235
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