Why the study?
Does CRT improve electrophysiological remodeling and mechanical performance in the failing heart?
Does CRT improve electrophysiological remodeling and mechanical performance in the failing heart?
CRT may suppress ventricular arrhythmias and contribute to mortality benefit by partially restoring electrophysiological remodeling and calcium homeostasis in the failing heart.
May reduce arrhythmias and mortality in HF; leaves open prospective clinical validation of mechanisms.
CRT partially restores DHF-induced electrophysiological remodeling, abnormal Ca homeostasis, blunted beta-adrenergic responsiveness, and regional heterogeneity of APD, and thus may suppress ventricular arrhythmias and contribute to the mortality benefit of CRT as well as improving mechanical performance of the heart.
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Aiba et al. (2009) studied this question.
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