Novel Approach for Assessing Postinfarct Myocardial Injury and Inflammation Using Hybrid Somatostatin Receptor Positron Emission Tomography/Magnetic Resonance Imaging

Figures

• 

  Figure 1.. Baseline 68Ga-DOTATATE positron emission tomography (PET)/magnetic resonance imaging (MRI) after myocardial infarction. A, Coronary angiography showing an occluded obtuse marginal branch of the left circumflex artery (arrow) at the time of initial myocardial infarction (MI) presentation; (B) 3-dimensional volume-rendered computed tomography coronary angiography after percutaneous coronary stenting (arrow). PET/MRI performed on day 11 post-infarct: (C, short-axis view; F, 3-chamber view) late gadolinium enhancement (LGE) MRI confirms areas of near full thickness basal infero-lateral MI (asterisk) and sub-endocardial mid to apical inferolateral infarction; (D) T1-mapping in basal short-axis view corroborating the extent of infarct (arrowhead); (E) increased 68Ga-DOTATATE PET uptake (dashed arrow) co-localizes with the area of infarct.

• 

  Figure 2.. Comparison of baseline and 3-month follow-up 68Ga-DOTATATE positron emission tomography (PET)/magnetic resonance imaging (MRI). Baseline PET/MRI: (A) Late gadolinium enhancement (LGE) MRI showing sub-endocardial myocardial infarction (asterisk) in the mid inferolateral segment, with corresponding (C) high signal (arrowhead) on T2-weighted imaging; and (G) increased 68Ga-DOTATATE PET uptake (dashed arrow). E, Color-map demonstrates myocardium-to-muscle T2 ratio. Follow-up PET/MRI performed 102 days postinfarct: (B) T2-mapping; (D) resolution of edema on T2-weighted imaging; (F) myocardium-to-muscle T2 ratio; (H) residual infarct-related 68Ga-DOTATATE signal (dashed arrow). LGE imaging was not repeated at follow-up.