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May aid MI characterization via macrophage imaging; hypothesis-generating and requires prospective validation before clinical use.
We could demonstrate in humans that USPIO-based contrast agents enable a more detailed characterization of myocardial infarct pathology mainly by detecting infiltrating macrophages. Considering the multi-functionality of USPIO-based particles and their superior safety profile compared with gadolinium-based compounds, these observations open up new vistas for the clinical application of USPIO.
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Yılmaz et al. (2012) studied this question.
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