In vitro study demonstrates effective exosome-mediated siRNA delivery and RAD51 knockdown in human cells, highlighting the potential of exosomes as cancer therapy vectors.
The results strongly suggest that exosomes effectively delivered the siRNA into the target cells. The therapeutic potential of exosome-mediated siRNA delivery was demonstrated in vitro by the strong knockdown of RAD51, a prospective therapeutic target for cancer cells. The results give an additional evidence of the ability to use human exosomes as vectors in cancer therapy, including RNAi-based gene therapy.
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Shtam et al. (2013) studied this question.
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