What question did this study set out to answer?

To determine whether transiently blocking NMDA glutamate receptors during late fetal or early neonatal life causes neurodegeneration in the developing central nervous system.

January 1, 1999Science

Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain

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Authors

CIChrysanthy IkonomidouUniversity of Wisconsin–Madison FBFriederike BoschHumboldt-Universität zu Berlin MMMichael MiksaNorthwell Health

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Implication

Preclinical study demonstrates widespread apoptotic neurodegeneration after NMDA receptor blockade in developing rats, highlighting potential risks of pediatric anesthesia.

Key Points

To determine whether transiently blocking NMDA glutamate receptors during late fetal or early neonatal life causes neurodegeneration in the developing central nervous system.
Administered NMDA receptor antagonists to block receptor function for several hours in rat models during late fetal or early neonatal periods.
Assessed brain tissue to identify the presence, extent, and distribution of apoptotic neurodegeneration.
Blockade of NMDA receptors for only a few hours triggered widespread apoptotic neurodegeneration throughout the developing brain.
Endogenous glutamate signaling at NMDA receptors was demonstrated to be a vital survival factor that protects developing neurons from programmed cell death.

Cite This Study

Ikonomidou et al. (1999) studied this question.

synapsesocial.com/papers/69d94b8f8988aeabbe684ba3 https://doi.org/10.1126/science.283.5398.70

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Implication

Preclinical study demonstrates widespread apoptotic neurodegeneration after NMDA receptor blockade in developing rats, highlighting potential risks of pediatric anesthesia.

Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain

Discussion

Member takes

Implication

Key Points

Cite This Study

Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain

Discussion

Member takes

Implication

Key Points

Cite This Study

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