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We detected H5N1 high pathogenicity avian influenza in captive Greater Rhea ( Rhea americana ). Viral genetic analysis revealed the mammalian associated PB2-E627K mutation, indicating selection of mammalian-relevant mutations in ratites. Pathologic investigation of available tissues demonstrated severe multifocal necrotising inflammation, and a strong vasculotropism.
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Coombes et al. (2025) studied this question.
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