Systematic review finds early neurological deterioration occurs in over 20% of acute lacunar ischemic stroke cases, indicating a key target for clinical trials.
END occurs in more than 20% of patients with acute lacunar ischemic stroke and might provide a novel target for clinical trials. A definition of an NIHSS ⩾2 decrease is most used and provides the best between-study homogeneity. END is consistently associated with poor functional outcome. Further research is needed to better identify patients at risk of END, to understand the underlying mechanisms, and to carry out new trials to test potential interventions.
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Werring et al. (2024) studied this question.
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