Why the study?
Although early neurological deterioration worsens acute ischemic stroke outcomes, standardized treatment strategies remain undefined, leading to variability in clinical practice.
Does induced hypertension or antithrombotics change improve neurological and functional outcomes in patients with noncardioembolic ischemic stroke who developed early neurological deterioration compared to conservative management?
Population
Patients with noncardioembolic stroke developing early neurological deterioration from stroke progression in South Korea
Comparison
Conservative management vs antithrombotics change vs induced hypertension
Design
Nationwide prospective multicenter registry-based cohort study
Follow-up
3 months
Key result
Induced hypertension increased the odds of neurological improvement (OR 1.55; 95% CI 1.25-1.92) compared with conservative management in patients with early neurological deterioration.
Authors
Loading...
Induced hypertension was associated with neurological improvement; hypothesis-generating and should not change practice pending randomized trials.
Cohort
Yes
Does induced hypertension or antithrombotics change improve neurological and functional outcomes in patients with noncardioembolic ischemic stroke who developed early neurological deterioration compared to conservative management?
Odds Ratio: 1.55 (95% CI 1.25–1.92)
p-value: p=<0.001
Induced hypertension is associated with favorable neurological and functional outcomes in patients with noncardioembolic ischemic stroke who develop early neurological deterioration.
Kim et al. (2025) conducted a cohort in Early neurological deterioration in noncardioembolic ischemic stroke. Induced hypertension vs. Conservative management was evaluated on Neurological improvement (≥2-point reduction in the National Institutes of Health Stroke Scale score) (OR 1.55, 95% CI 1.25-1.92, p=<0.001). Induced hypertension increased the odds of neurological improvement (OR 1.55; 95% CI 1.25-1.92) compared with conservative management in patients with early neurological deterioration.