March 1, 2002Development

Drosophilamyosin phosphatase and its role in dorsal closure

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Population

Drosophila embryos (defective for maternal and zygotic DMBS, or overexpressing Rho-kinase)

Design

Preclinical

Authors

TMTomoaki MizunoUniversity of Tsukuba KTKyoko TsutsuiUniversity of Tsukuba YNYasuyoshi NishidaFox Chase Cancer Center

Discussion

Member takes

Implication

Myosin phosphatase is required for epithelial morphogenesis in Drosophila; leaves open conserved roles in vertebrate development.

Structured PICO

Population

Drosophila embryos (defective for maternal and zygotic DMBS, or overexpressing Rho-kinase)

Intervention

Mutation of DMBS (Drosophila homolog of MBS) or overexpression of Rho-kinase

Outcome

Dorsal closure and cell shape change during morphogenesis

Myosin phosphatase plays an important role in morphogenesis by repressing the activation of nonmuscle myosin II for coordinated cell shape change, functioning antagonistically to the Rho signaling pathway.

Cite This Study

Mizuno et al. (2002) studied this question.

synapsesocial.com/papers/69d95f3cc7f0c3ae80a3d370 https://doi.org/10.1242/dev.129.5.1215

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Drosophilamyosin phosphatase and its role in dorsal closure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Drosophilamyosin phosphatase and its role in dorsal closure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider