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This review explores the evolution and functional significance of the CD38 gene family in health and disease states.

Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology

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Review examines the roles of CD38 and CD157 in various diseases, highlighting their potential as biomarkers and therapeutic targets.

This review explores the evolution and functional significance of the CD38 gene family in health and disease states.
Reviewed literature on CD38 and CD157 functions and their enzymatic activities.
Analyzed the implications of CD38 loss in metabolic and immune dysfunction in mice.
Contextualized findings for potential clinical applications in human diseases.
CD38 loss correlates with impaired immune response and metabolic disturbances in mice.
CD38 serves as a key disease marker in human leukemias and myelomas, influencing outcomes.
CD38 regulates insulin release and is implicated in diabetes development.

Malavasi et al. (2008) studied this question.

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