Genetic interaction by reassortment among cocirculating rotaviruses is not a rare event and contributes significantly to their overall diversity.
The G and P genotypes of 3,601 rotavirus strains collected in the United Kingdom between 1995 and 1999 were determined (M. Iturriza-Gómara et al., J. Clin. Microbiol. 38:4394-4401, 2000). In 95.4% of the strains the most common G and P combinations, G1P8, G2P4, G3P8, and G4P8, were found. A small but significant number (2%) of isolates from the remaining strains were reassortants of the most common cocirculating strains, e.g., G1P4 and G2P8. Rotavirus G9P6 and G9P8 strains, which constituted 2.7% of all viruses, were genetically closely related in their G components, but the P components of the G9P8 strains were very closely related to those of cocirculating strains of the more common G types (G1, G3, and G4). In conclusion, genetic interaction by reassortment among cocirculating rotaviruses is not a rare event and contributes significantly to their overall diversity.
Iturriza‐Gómara et al. (Sun,) studied this question.
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