Preclinical study reveals stromal CXCL10 recruits immunosuppressive regulatory T cells in pancreatic ductal adenocarcinoma, indicating a key pathway driving tumor progression.
Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10.
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Lunardi et al. (2015) studied this question.
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