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July 12, 2026Translational OncologyOpen Access

CXCL11 recruits immunosuppressive cells to form a barrier at the invasive front of pancreatic cancer by activating the NF-κB/CCL2 axis

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Authors

FWFang WeiLYL YangXZXianghai Zeng

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Overview

Randomized trial demonstrates CXCL11's role in forming immunosuppressive barriers in pancreatic cancer, indicating potential therapeutic targets.

Key Points

  • This study aims to elucidate the role of CXCL11 in the immunosuppressive microenvironment of pancreatic cancer and its implications for patient prognosis.
  • Integrated clinical cohort analysis and tissue microarray to assess CXCL11 expression.
  • Conducted transcriptomic sequencing and functional experiments to explore molecular mechanisms, including NF-κB activation.
  • Established CXCL11 knockdown and overexpression models in Panc02 and SW1990 cell lines and analyzed protein expression through western blotting.
  • CXCL11 expression was significantly higher in paratumor tissues compared to tumor tissues, correlating with poor prognosis.
  • Co-enrichment of CXCL11 with immunosuppressive markers (CD163, CD11b) indicates its role in forming an immunosuppressive barrier.
  • Transcriptomic analysis confirmed CXCL11's activation of the NF-κB signaling pathway and its role in upregulating CCL2 expression.

Cite This Study

Wei et al. (2026) studied this question.

synapsesocial.com/papers/6a532e624f7abc118adecb88https://doi.org/10.1016/j.tranon.2026.102909
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CCL19 Suppresses Pancreatic Cancer Progression via Immune Microenvironment Remodeling: Bioinformatics and Functional Insights2025
  2. 2Dual-faced CXCL5 holds the key to unlocking immunotherapy in obese pancreatic cancer2025
  3. 3CXCL13 as a Prognostic Biomarker and Modulator of the Tumor Microenvironment in Colorectal Cancer.2025 · 4 citations
  4. 4Abstract A095: Oncogenic KRAS signaling mediates NF-kB induced chemokine production by pancreas tumor cell2025
  5. 5<i>CXCL12</i> Expression and Clinicopathological Features at the Invasive Front of Pancreatic Cancer2026