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September 5, 2025Journal for ImmunoTherapy of CancerOpen Access

Dual-faced CXCL5 holds the key to unlocking immunotherapy in obese pancreatic cancer

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Authors

LLLiping LiangYZYongjian ZhouLLLe Liu

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Overview

This commentary reveals how CXCL5 mediates immune suppression in PDAC, suggesting dual targeting may enhance immunotherapy outcomes.

Key Points

  • CXCL5 ablation facilitates CD8+ T-cell infiltration in PDAC models, indicating a potential immunotherapy strategy.
  • Findings show that obesity exacerbates immune evasion in PDAC through CXCL5 and metabolic inflammation.
  • Dual targeting of CXCL5 and programmed cell death protein-1 may provide therapeutic improvements in treating PDAC.
  • Understanding chemokine signaling like that of CXCL5 is crucial for advancing immunotherapy in obese cancer patients.

Cite This Study

Liang et al. (2025) studied this question.

synapsesocial.com/papers/68bb3a352b87ece8dc954df1https://doi.org/10.1136/jitc-2025-012566
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CXCL11 recruits immunosuppressive cells to form a barrier at the invasive front of pancreatic cancer by activating the NF-κB/CCL2 axis2026
  2. 2CCR-CCL Axes as Key Upstream Influencers of Immune Evasion, TME Remodeling, and Metastasis in Pancreatic Ductal Adenocarcinoma: CCR2–CCL2, CCR5–CCL5, CCR4–CCL17/22, CCR6–CCL20, CCR7–CCL19/212025
  3. 3OC45 - IL-1β/CXCL12 axis drives the crosstalk between PanNET cells and adipocytes2025
  4. 4Pancreatic ductal adenocarcinoma: integrating molecular insights for targeted interventions2026 · 3 citations
  5. 5A phase 2 trial of CXCR4 antagonism and PD1 inhibition in metastatic pancreatic adenocarcinoma reveals recruitment of T cells but also immunosuppressive macrophages2025 · 27 citations