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September 19, 2025Open Access

CCR-CCL Axes as Key Upstream Influencers of Immune Evasion, TME Remodeling, and Metastasis in Pancreatic Ductal Adenocarcinoma: CCR2–CCL2, CCR5–CCL5, CCR4–CCL17/22, CCR6–CCL20, CCR7–CCL19/21

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Authors

IBIngyu Bahng

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Overview

This review explores immunosuppressive effects and chemokine axes in PDAC, highlighting therapeutic efforts.

Key Points

  • Chemokine signaling pathways, specifically CCR-CCL axes, drive immune evasion and tumor progression in PDAC.
  • Key axes, including CCR2–CCL2 and CCR5–CCL5, influence regulatory immune cell recruitment, promoting metastasis.
  • The review assesses various small-molecule antagonists and monoclonal antibodies targeting these axes in PDAC.
  • Addressing research gaps in spatial profiling and mechanistic validation will enhance future PDAC therapeutic strategies.

Cite This Study

Ingyu Bahng (2025) studied this question.

synapsesocial.com/papers/68d464e031b076d99fa63d12https://doi.org/10.20944/preprints202509.1420.v1
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Also Consider

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  1. 1Dual-faced CXCL5 holds the key to unlocking immunotherapy in obese pancreatic cancer2025
  2. 2Abstract A095: Oncogenic KRAS signaling mediates NF-kB induced chemokine production by pancreas tumor cell2025
  3. 3Immune Evasion in Pancreatic Ductal Adenocarcinoma: Mechanistic Insights and Emerging Strategies to Reinvigorate Anti-Cancer Immunity2026
  4. 4A phase 2 trial of CXCR4 antagonism and PD1 inhibition in metastatic pancreatic adenocarcinoma reveals recruitment of T cells but also immunosuppressive macrophages2025 · 27 citations
  5. 5CXCL11 recruits immunosuppressive cells to form a barrier at the invasive front of pancreatic cancer by activating the NF-κB/CCL2 axis2026