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September 23, 2025European Journal of EndocrinologyOpen Access

OC45 - IL-1β/CXCL12 axis drives the crosstalk between PanNET cells and adipocytes

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Authors

MOMonica OldaniIRIlona RybińskaEGElisa Grassi

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Overview

This research reveals that IL-1β and CXCL12 enhance tumor growth via adipocyte reprogramming, indicating a vital inflammatory axis.

Key Points

  • Crosstalk between PanNET cells and adipocytes promotes tumor growth through IL-1β and CXCL12.
  • Indirect co-culture of PanNET cells with adipocytes triggered significant phenotypic changes in adipocytes.
  • Pharmacological inhibition of CXCR4 reduced IL-1β levels and tumor cell proliferation, showing potential therapeutic effects.
  • Findings suggest that obesity-related adipose tissue may exacerbate PanNET progression via inflammatory signaling.

Cite This Study

Oldani et al. (2025) studied this question.

synapsesocial.com/papers/68d4724f31b076d99fa6ac98https://doi.org/10.1093/ejendo/lvaf168.082
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IL-1β/CXCL12 signalling orchestrates adipocyte–pancreatic neuroendocrine tumor crosstalk2026
  2. 2Abstract LB231: Intra-pancreatic adipocytes promote pancreatic cancer progression by inhibiting tumor immunity2026
  3. 3Dual-faced CXCL5 holds the key to unlocking immunotherapy in obese pancreatic cancer2025
  4. 4Cancer-associated adipocytes: metabolic reprogramming, crosstalk and therapeutic implications in tumor progression2026
  5. 5Neutrophil extracellular traps induced by tumour-derived NGAL reprogram CAF subtypes via ITGA5 to promote tumour progression in pancreatic cancer2026