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September 10, 2025Cell Death DiscoveryOpen Access

Adipocyte-derived IL6 and triple-negative breast cancer cell-derived CXCL1 co-activate STAT3/NF-κB pathway to mediate the crosstalk between adipocytes and triple-negative breast cancer cells

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Authors

GRGuo‐Tian RuanLZLi‐Chen ZhuHXHailun Xie

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Overview

This analysis reveals how adipocyte-derived IL6 and TNBC cell-derived CXCL1 interact, enhancing cancer progression.

Key Points

  • Co-culture of adipocytes with TNBC cells enhances cell invasion abilities, driving tumor progression.
  • CXCL1 from TNBC cells activates the STAT3/NF-κB pathway, while adipocytes secrete IL6, promoting invasion.
  • Methods included wound healing and Transwell assays to assess invasion, alongside RT-PCR and ELISA for gene expression.
  • Findings suggest that targeting adipocyte-TNBC interactions could lead to new treatment strategies for advanced TNBC cases.

Cite This Study

Ruan et al. (2025) studied this question.

synapsesocial.com/papers/68c1ce5d54b1d3bfb60f51echttps://doi.org/10.1038/s41420-025-02713-4
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