Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
August 28, 2020Molecular Cancer ResearchOpen Access

Secreted Factors from Adipose Tissue Reprogram Tumor Lipid Metabolism and Induce Motility by Modulating PPARα/ANGPTL4 and FAK

View Full Paper
Ask AI
Bookmark
Share

Why the study?

The detailed mechanisms by which hypertrophic adipose tissue in obesity influences breast cancer cells were not well understood.

Population

TNBC cells exposed to adipose tissue from obese C57BL/6 mice or ACM from obese female patients

Design

Preclinical in vitro co-culture and mechanistic study

Authors

CBChristina BlücherSISabine IberlNSNancy Schwagarus

Discussion

Loading...

Member takes

Overview

Obesity-adipose effects on TNBC transcriptomes merit patient validation; hypothesis-generating and should not yet change practice.

Structured PICO

P
Population
Triple-negative breast cancer (TNBC) cells co-cultured with adipose tissue from high-fat diet induced obese C57BL/6 mice or treated with adipose tissue conditioned media (ACM) from obese female patients
I
Intervention
Co-culture with adipose tissue or treatment with adipose tissue conditioned media (ACM)
O
Outcome
Transcriptome profiles, lipid metabolism (β-oxidation), and cell phenotype (wound healing, proliferation, invasion)surrogate

Factors released by hypertrophic adipose tissue promote a more aggressive phenotype in triple-negative breast cancer cells via PPAR-regulated lipid metabolism and FAK signaling.

Cite This Study

Blücher et al. (2020) studied this question.

synapsesocial.com/papers/6a70e2d678a11c550e0ae6e1https://doi.org/10.1158/1541-7786.mcr-19-1223
View Full Paper
Ask AI
Bookmark
Share