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June 20, 2026Journal of Translational MedicineOpen Access

IL-1β/CXCL12 signalling orchestrates adipocyte–pancreatic neuroendocrine tumor crosstalk

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Authors

MOMonica OldaniIRCCS Istituto Auxologico ItalianoEGElisa GrassiIRCCS Istituto Auxologico ItalianoGGGermano GaudenziIRCCS Istituto Auxologico Italiano

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Overview

Randomized trial investigates IL-1β/CXCL12 role in adipocyte-PanNET crosstalk, suggesting therapeutic potential.

Key Points

  • The study aims to clarify the crosstalk mechanisms between adipocytes and pancreatic neuroendocrine tumor cells.
  • Investigated adipocyte and PanNET cell interactions using indirect co-culture systems and conditioned media from 3T3-L1 adipocytes.
  • Examined the effects of IL-1β and CXCL12 on adipocyte reprogramming and tumor cell proliferation.
  • Utilized pharmacological agents like AMD3100 and canakinumab to disrupt signaling pathways.
  • PanNET cells induced adipocyte reprogramming to a cancer-associated phenotype, significantly reducing adipogenic markers.
  • IL-1β was identified as a key driver of this reprogramming, while CXCL12 enhanced PanNET cell proliferation and IL-1β release.
  • Blocking the IL-1β/CXCL12 axis reduced both tumor cell proliferation and adipocyte reprogramming.

Cite This Study

Oldani et al. (2026) studied this question.

synapsesocial.com/papers/6a362f3bdb0793dc1a536b91https://doi.org/10.1186/s12967-026-08428-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1OC45 - IL-1β/CXCL12 axis drives the crosstalk between PanNET cells and adipocytes2025
  2. 2Adipocyte-derived IL6 and triple-negative breast cancer cell-derived CXCL1 co-activate STAT3/NF-κB pathway to mediate the crosstalk between adipocytes and triple-negative breast cancer cells2025 · 10 citations
  3. 3Dual-faced CXCL5 holds the key to unlocking immunotherapy in obese pancreatic cancer2025
  4. 4Abstract LB231: Intra-pancreatic adipocytes promote pancreatic cancer progression by inhibiting tumor immunity2026
  5. 5Neutrophil extracellular traps induced by tumour-derived NGAL reprogram CAF subtypes via ITGA5 to promote tumour progression in pancreatic cancer2026