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September 5, 2025Open Access

CCL19 Suppresses Pancreatic Cancer Progression via Immune Microenvironment Remodeling: Bioinformatics and Functional Insights

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Authors

XWXiao WuAZAndrew X. ZhuTWTingting Wang

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Overview

Bioinformatics analysis reveals CCL19's influence on macrophage polarization and tumor growth in pancreatic cancer.

Key Points

  • CCL19 overexpression significantly reduces pancreatic cancer cell proliferation and migration, improving outcomes.
  • Analysis identified six hub genes, including CCL19, that regulate immune pathways critical to pancreatic cancer.
  • Functional experiments showed CCL19 promotes anti-tumoral macrophage polarization, indicating its therapeutic potential.
  • Elevated CCL19 levels correlate with better patient survival rates, supporting its role in immunotherapy strategies.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd026dahttps://doi.org/10.21203/rs.3.rs-7426239/v1
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Also Consider

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  1. 1CXCL11 recruits immunosuppressive cells to form a barrier at the invasive front of pancreatic cancer by activating the NF-κB/CCL2 axis2026
  2. 2Targeting CCR1 remodels the tumor microenvironment and relieves immune suppression in pancreatic cancer2026
  3. 3Abstract 1593: Intercellular network in immune suppressive microenvironment of pancreatic cancer2024
  4. 4CXCL13 as a Prognostic Biomarker and Modulator of the Tumor Microenvironment in Colorectal Cancer.2025 · 4 citations
  5. 5CXCL12 derived from cancer-associated fibroblasts mediates dysfunctional intratumoral adaptive immunity in diabetic pancreatic adenocarcinoma2025