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September 12, 2025Open Access

CXCL12 derived from cancer-associated fibroblasts mediates dysfunctional intratumoral adaptive immunity in diabetic pancreatic adenocarcinoma

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Authors

JWJialun WangYZYue ZhouXHXiaoxuan Han

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Overview

Analysis reveals dysfunctional immunity in diabetic pancreatic adenocarcinoma, indicating CXCL12's role in immune modulation.

Key Points

  • The immune environment in diabetic pancreatic cancer appears active but is functionally impaired, affecting T and B cells.
  • CXCL12 expression correlates with immune cell types and their transformation in the tumor microenvironment.
  • Enrichment analyses highlight immune-related pathways influenced by cancer-associated fibroblasts in diabetes.
  • Targeting CXCL12-CXCR4 signaling showed promising therapeutic benefits in experimental models of pancreatic cancer.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68d44c3d31b076d99fa55941https://doi.org/10.21203/rs.3.rs-7429791/v1
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