This study provides the first evidence that Rap1b in smooth muscle and endothelium is required for maintaining normal blood pressure and vascular tone.
Hypothesis-generating for Rap1b in vascular tone; clinical relevance requires human studies.
This is the first report to indicate that Rap1b in both smooth muscle and endothelium plays a key role in maintaining blood pressure by controlling normal vascular tone.
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Lakshmikanthan et al. (2014) studied this question.
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