Inflammatory cytokines and lung egg burden may drive pulmonary vascular remodeling in schistosomiasis, even before right ventricular hypertrophy develops.
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Suggests cytokine or egg-driven remodeling precedes RV changes in schistosomiasis; hypothesis-generating for human validation and targeted therapies.
This study provides evidence for extensive pulmonary vascular remodeling, despite the absence of RV hypertrophy, in a mouse model of schistosomiasis, including the formation of plexiform-like lesions. Inflammatory cytokines and lung egg burden may contribute to vascular lesion formation.
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Crosby et al. (2009) studied this question.
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