Acute hyperglycemia worsens neuroinflammation and cognitive impairment in sepsis-associated encephalopathy via the ChREBP/HIF-1α pathway.
These results collectively suggest that hyperglycemia can exacerbate neuroinflammation and delirium by enhancing microglial glycolysis under septic conditions, potentially mediated by upregulation of the ChREBP/HIF-1α signaling pathway.
Yao et al. (Thu,) studied this question.